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Rowland and Tozer’s clinical pharmacokinetics and pharmacodynamics : concepts and applications
Abstract
Indice dei contenuti: 1. Basic considerations: Therapeutic relevance - Fundamental concepts and terminology - 2. Exposure and response after a single dose: Kinetics following an intravenous bolus dose - Membranes and distribution - Elimination - Kinetics following an extravascular dose - Absorption - Response - 3. Therapeutic window - Constant-rate input - Multiple-dose regimens - 4.
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Individualization: Variability - Genetics - Age, weight, and gender - Disease - Nonlinearities - Drug interactions - Initiating and managing therapy - 5. Supplemental topics: Distribution kinetics - Metabolites and drug response - Protein drugs - Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data - Appendix A: Assessment of AUC - Appendix B: Ionization and the pH partition hypothesis - Appendix C: Distribution of drugs extensively bound to plasma proteins - Appendix D: Plasma-to-blood concentration ratio - Appendix E: Well-stirred model of hepatic clearance - Appendix F: Absorption kinetics - Appendix G: Wagner-Nelson method - Appendix H: Mean residence time - Appendix I: Amount of drug in body on accumulation to plateau - Appendix J: Introduction to MS excel simulations - Appendix K: Answers to study problems - Index
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